Captopril Triumph.
By Telesphory Wamara And Sarafina Msigwa The deadly South American pit viper (Bothrops jararaca) is known for its deadly venom ,it kills its prey through injection of venom, once injected in prey the venom has remarkable ability of causing high drop in blood pressure consequently causing instant death. The venom that produces this result solves the snake’s dietary problem promptly because it can now catch up with its immobilized victim and consume it. A few insightful scientists understanding these considerations recognized the potential value of snake venom to control malignant blood pressure if administered carefully to sufferers. The design of the antihypertensive drug captopril, a clinically important and potent reversible inhibitor of ACE, is an example of one of the early endeavors and successes of a rationally designed enzyme inhibitor, and one among of its design ideas comes from the pit viper snake venom. By about 1965 it was found that the active principles in the ven