Posts

Showing posts from May, 2023

Captopril Triumph.

By Telesphory Wamara And Sarafina Msigwa The   deadly South American pit viper (Bothrops jararaca)  is known for its deadly venom ,it kills its prey through injection of venom, once injected in prey the venom has remarkable ability of causing high drop in blood  pressure consequently causing instant death. The venom that produces this result  solves the snake’s dietary problem promptly because it can now catch up with its immobilized victim and consume it. A few insightful scientists understanding these considerations recognized the potential value of snake venom to control malignant blood pressure if administered carefully to sufferers. The design of the antihypertensive drug captopril, a clinically important and potent reversible inhibitor of ACE, is an example of one of the early endeavors and successes of a rationally designed enzyme inhibitor, and one among of its design ideas comes from the pit viper snake venom. By about 1965 it was found that the active principles in the ven

Food Drugs interactions

 By Sarafina Msigwa and Telesphory Wamara Ever wondered why you are instructed to take or not to take a certain food while you are on a certain medication dosage?. Food has either positive or negative effects on bioavailability of a drug, on the other hand drugs also affect the way body utilizes food.  Some interactions are common or well known by people while others are not, It is important to know how these interactions occur. On this writing you are also going to see interactions of drugs with beverages and dietary supplements  While these interactions may have an advantage but in most cases they result into adverse drug reactions making it very important for physicians to provide correct and full information to the patients who should also adhere to the instructions. 1.       GRAPE FRUIT JUICE (GFJ) The grape fruit juice is one among fruit juices having interaction with almost all types of drugs. Its main effects results from its ability to change metabolism of medications by the b