GLIMPSE ON PHARMACOGENOMICS From DawaSpace. Pharmacogenomics is the study of how differences in genetic factors in different individuals affec t their response to drugs. It was commonly understood that our genetic factors play a role in how we respond to drugs, but the fact that the variations in genetic factors among individual could affect how we respond to drugs was yet to be established. The Pharmacogenetics field began when certain individual who had genetic variation in enzyme responsible for metabolizing drugs experienced abnormally severe drug reaction. The sequencing of human genome has contributed a lot to the development of this study. In 1957 the geneticist Arno Motulsky Published an article that highlighted the evidence that the antimalaria drug primaquine and the muscle relaxant suxamethonium chloride , possessed the adverse drug reactions that were heritable and linked to deficit in specific enzymes. Below are the scenarios in w
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